Imatinib 400 mg Tablet (Celltinib)

Celltinib 400mg is applied in the treatment of blood cancer or chronic myeloid leukaemia and gastrointestinal stromal tumour. Its active ingredient works on specific tumour growth signals without attacking all rapidly dividing cells.

What is Imatinib 400 mg?

Imatinib 400 mg is a targeted anticancer drug which includes imatinib as the active ingredient. It is used to treat chronic myeloid leukaemia and gastrointestinal stromal tumour. It is applied to patients who require long-term, supervised cancer treatment. This medicine is manufactured by American Remedies Pvt. Ltd.

It targets certain abnormal proteins that aid the growth of the cancerous cells, as opposed to general chemotherapy. Imatinib 400mg uses slow down the progression of the disease, decrease tumor activity, and help maintain remission in many patients when taken according to schedule.

Uses of Imatinib 400 mg Tablet

Chronic Myeloid Leukaemia and Gastrointestinal Stromal Tumour

The production of abnormal white blood cells is inhibited by imatinib. It aids in reducing cancer cells, promoting remission, and slowing down disease progression. It is applied to tumours of the digestive tract, which are caused by abnormal growth signals. It can either reduce the size of tumours or slow further growth. It can also be prescribed by doctors for related conditions with similar abnormal tyrosine kinase activity.

How Imatinib Works in the Body

Chronic Myeloid Leukaemia

400mg Imatinib inhibits BCR-ABL, which is formed as one of the tyrosine kinases by the Philadelphia chromosome abnormality. This abnormal protein transmits continuous signals for excessive white blood cell growth. By halting this signal, the medicine lowers the multiplication of cancer cells and assists normal blood cells to rejuvenate. It can also help to balance the blood count and decrease the activity of the disease, and the probability of its progression to advanced treatment-resistant stages.

Gastrointestinal Stromal Tumour

A variety of GIST tumours are reliant on the presence of the abnormal KIT or PDGF receptor proteins. Imatinib inhibits these proteins and disrupts signals that boost tumour survival and proliferation. Consequently, the growth of tumours can be slowed, the tumour may decrease in size, and the progression of the disease can be controlled. It may also assist in the stabilisation of tumours, delay recurrence post-operation, and enhance responses in advanced tumours.

Dosage Guidelines and Administration

Follow the directions of your cancer specialist for taking this medication. It is normally administered once a day along with food and water to minimise stomach irritation. Take the pill whole unless instructed otherwise by your doctor.

Missed Dose:

• Take it when you remember, but if it’s time to take your next due dose; never take two doses.

Overdose:

• Immediately contact medical assistance in case of taking an overdose by accident.

How to Take Imatinib 400 mg Tablet

• Take the Imatinib 400mg tab once a day with a meal.
• Swallow it with water.
• Do not crush unless instructed by the doctor.

Benefits of Imatinib 400 mg (Celltinib)

Physical Benefits

• Lowers levels of abnormal white blood cells.
• Aids in attaining hematologic remission.
• Slows progression to advanced stages.
• Aids in healthier bone marrow function.
• Slows the growth rate of tumours.
• Lowers the risk of tumour spread.

Psychological Benefits

• Increased confidence from consistent treatment effectiveness.
• Reduced worry about a fast progression.
• Increases hope due to targeted response to cancer therapy.
• Less stress following control of tumours.

Possible Side Effects and Risks

The side effects of the Imatinib tablet 400 mg are usually manageable; however, when closely monitored, most patients are able to tolerate imatinib. There are mild effects that get better with time, and some users might require medical attention. See your doctor in case of severe or persistent symptoms.

• Nausea
• Vomiting
• Diarrhoea
• Swelling around the eyes
• Muscle cramps
• Skin rash
• Tiredness
• Headache
• Abdominal discomfort
• Fluid retention

Drug Interactions to Be Aware Of

Imatinib can interact with other drugs that affect liver enzymes, heart rhythm, and bleeding risk. Always take your complete medicine list to your doctor. Do not initiate new medicines without approval during treatment.

• Warfarin
• Rifampicin
• Ketoconazole
• Clarithromycin
• Phenytoin
• Carbamazepine
• Dexamethasone
• St. John’s Wort
• Erythromycin

Precautions and Warnings

• Use only under the supervision of an oncology specialist.
• Tell the doctor about any history of liver disease.
• In case of a sudden increase in weight, report it immediately.
• Avoid pregnancy when taking the drug.
• Regularly attend blood test appointments.
• Continue until the doctor advises otherwise.
• Report abnormal swelling to the doctor.
• Do not have surgery without notifying your doctor.
• Store at 20°C to 25°C (68°F to 77°F). Secure away from moisture, heat, and sunlight. Keep away from children.

Did you know?

Imatinib was one of the first successful targeted cancer therapies and transformed the treatment of mutation-driven cancers worldwide

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